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FLASH GENE

Symbol

STEAP4

contributors: mct - updated : 04-06-2014

HGNC name	STEAP family member 4
HGNC id	21923

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate cancer cells compared with normal prostate epithelial cells constitutional     --other   deficiency is sufficient to spontaneously recapitulate many cardinal features of the metabolic syndrome, including inflammation, insulin resistance, glucose intolerance, mild hyperglycemia, dyslipidemia, and fatty infiltration of liver constitutional     --over   can improve glucose uptake and mitochondrial function, and increase insulin sensitivity constitutional     --over   during osteoclast differentiation constitutional     --low   might reflect visceral adipose dysfunction in subjects with obesity and type 2 diabetes constitutional     --low   in metabolic syndrome, especially women patients, down-regulated in peripheral blood mononuclear cell, which was correlated with carotid atherosclerosis and cardiac adaptation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	STEAP4-deficiency in mice leads to overt inflammation and development of spontaneous metabolic disease on a regular diet characterized by insulin resistance, glucose intolerance, mild hyperglycemia, dyslipidemia, and fatty liver disease (Kralisch 2009)
	loss of Steap4 expression in mice leads to increased production of inflammatory cytokines in visceral white adipose tissue and systemic insulin resistance