SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
text
| primarily localized to the Golgi complex, trans-Golgi network, and the plasma membrane |
|
also localizes to vesicular-tubular structures in the cytosol and colocalizes with the Early Endosome Antigen1 (EEA1) |
|
resides predominantly in endosomes and may functions as a ferrireductase in osteoclast lineage cells as it does in other cells |
basic FUNCTION
| may be participating in adipocyte development and metabolism and mediating some TNF alpha effects on the fat cell as a channel or a transporter |
|
may contribute to the normal biology of the prostate cell, as well as prostate cancer progression |
|
critical modulator of this integrated response system of inflammation and metabolism in adipocytes |
|
participating in integrating inflammatory and metabolic responses and thus playing a key role in systemic metabolic homeostasis |
|
acting in a similar regulatory capacity in response to acute nutritional challenges or chronic hyperglycemia |
|
might modulate proinflammatory and insulin resistance-inducing effects of IL1B (Kralisch 2009) |
|
plasma membrane metalloreductase involved in the transport of iron and copper |
|
transcriptional regulation of hepatic STEAP4 may play a critical role in the response to nutritional and inflammatory stress and contributes to the protective effect of STEAP4 |
|
STEAP1, STEAP2, STEAP3, STEAP4 share an innate activity as metalloreductases, indicating their importance in metal metabolism |
|
STEAP4 and LCN2 mRNA and protein levels in visceral adipose tissue are related to iron status |
|
is a critical enzyme for cellular iron uptake and utilization in osteoclasts and, thus, indispensable for osteoclast development and function |
|
is a novel anti-obesity gene that is significantly down-regulated in adipose tissue of obese patients |
| may be involved in the secretory/endocytic pathways |
protein
| TNF, IL6, and leptin, which have been implicated in insulin sensitivity regulation, regulate the expression of STEAP4 |
activated by
| IL1B in a dose- and time-dependent fashion in 3T3-L1 adipocytes (Kralisch 2009) |
induced by
| interleukin 6 (IL6) |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in prostate cancer cells compared with normal prostate epithelial cells | constitutional
|  
|  
| --other
|  
|
deficiency is sufficient to spontaneously recapitulate many cardinal features of the metabolic syndrome, including inflammation, insulin resistance, glucose intolerance, mild hyperglycemia, dyslipidemia, and fatty infiltration of liver | constitutional
|  
|  
| --over
|  
|
can improve glucose uptake and mitochondrial function, and increase insulin sensitivity | constitutional
|  
|  
| --over
|  
|
during osteoclast differentiation | constitutional
|  
|  
| --low
|  
|
might reflect visceral adipose dysfunction in subjects with obesity and type 2 diabetes | constitutional
|  
|  
| --low
|  
|
in metabolic syndrome, especially women patients, down-regulated in peripheral blood mononuclear cell, which was correlated with carotid atherosclerosis and cardiac adaptation | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
| | | |
| STEAP4-deficiency in mice leads to overt inflammation and development of spontaneous metabolic disease on a regular diet characterized by insulin resistance, glucose intolerance, mild hyperglycemia, dyslipidemia, and fatty liver disease (Kralisch 2009) | |
loss of Steap4 expression in mice leads to increased production of inflammatory cytokines in visceral white adipose tissue and systemic insulin resistance |