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FLASH GENE
Symbol ENDOU contributors: mct/ - updated : 18/09/2008
HGNC name endonuclease, polyU-specific
HGNC id 14369
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • an N-terminal hydrophobic region of 18 amino acids typical of secretory proteins (signal peptide of 1.9 kda)
  • a SMB domain
    • isoforms Precursor a 350 aa mature peptide of 40.2 kda
    HOMOLOGY
    interspecies ortholog to murine Pp11r (84.8pc)
    Homologene
    FAMILY
  • ENDOU family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a putative serine protease
  • can act as a tumor marker because of its specific association with various forms of cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HTR1B (its overexpression increasing HTR1B function)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS