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FLASH GENE
Symbol ENDOU contributors: mct/ - updated : 18/09/2008
HGNC name endonuclease, polyU-specific
HGNC id 14369
Location 12q13.11      Physical location : 48.103.519 - 48.119.355
Synonym name
  • 22 serine protease
  • placental protein 11
  • protein endoU
  • 26 serine protease
    • Synonym symbol(s) PP11, PRSS26, MGC133268, P11
    EC.number 3.4.21.-, 3.1.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 15.82 kb     9 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2474 - 410 - -
    - - 2285 - 347 - -
    9 - 2351 - 369 - PMID: 1710108
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     mouthtongue  moderately
    Reproductivefemale systemplacenta  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • an N-terminal hydrophobic region of 18 amino acids typical of secretory proteins (signal peptide of 1.9 kda)
  • a SMB domain
    • isoforms Precursor a 350 aa mature peptide of 40.2 kda
    HOMOLOGY
    interspecies ortholog to murine Pp11r (84.8pc)
    Homologene
    FAMILY
  • ENDOU family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a putative serine protease
  • can act as a tumor marker because of its specific association with various forms of cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HTR1B (its overexpression increasing HTR1B function)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS