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FLASH GENE

Symbol

BCORL1

contributors: mct - updated : 17-03-2021

HGNC name	BCL6 co-repressor-like 1
HGNC id	25657

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a nuclear localization signal
	three ANK repeats

HOMOLOGY

interspecies	homolog to rattus Bcorl1 (91.5 pc)
	homolog to murine Bcorl1 (89.7 pc)

intraspecies

homolog to BCOR

Homologene

FAMILY

BCOR family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	acting as a transcriptional corepressor
	may specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6
	associated with histone deacetylase (HDAC) activity
	transcriptional corepressor, involved in negative gene regulation through associations with several protein complexes including Class II histone deacetylases (HDACs)
	is contributor to spermatogenesis

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with CTBP1
	interacting with HDAC4, HDAC5 and HDAC7

cell & other

REGULATION

Other

phosphorylated upon DNA damage, probably by ATM or ATR

ASSOCIATED DISORDERS

corresponding disease(s)

IDBDD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   decrease with age, and age-associated BCORL1 down-regulation might potentially contribute to age-related epigenetic alterations and form a predisposing condition for the development of elderly AML

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Bcorl1 knockout mice were infertile with impaired spermatogenesis