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FLASH GENE
Symbol EIF4E3 contributors: mct - updated : 06-05-2015
HGNC name eukaryotic translation initiation factor 4E family member 3
HGNC id 31837
Location 3p13      Physical location : 71.728.441 - 71.803.924
Synonym name eukaryotic translation initiation factor 4E member 3
Synonym symbol(s) MGC39820, MGC86971
DNA
TYPE functioning gene
STRUCTURE 75.49 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 6185 - 118 - 2003 1515310
  • isoform b
  • 8 - 6222 - 118 - 2003 1515310
  • isoform b
  • 8 - 6100 - 118 - 2003 1515310
  • isoform b
  • 7 - 6091 - 224 - 2003 1515310
  • isoform a
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiensAdult
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunespleen   highly Homo sapiensAdult
    Respiratorylung   highly Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal   Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    secondary structure
  • retain the eIF4E fold of a central curved beta-sheet consisting of seven antiparallel beta-strands flanked by three alpha helices at its convex surface
  • HOMOLOGY
    interspecies homolog to murine Eif4e3 (94.7pc)
    homolog to rattus Eif4e3 (94.7pc)
    Homologene
    FAMILY
  • eukaryotic initiation factor 4E family
  • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • EIF4E3 is in the nucleus and cytoplasm
  • basic FUNCTION
  • translational initiation factor that interacts with the 5' CAP strucutre of mRNA and recruits mRNA to the ribosome
  • may act as an inhibitor of EIF4E activity
  • is an inhibitor, rather than a promoter, of both target transcript expression and oncogenic transformation
  • EIF4E3 repressed the expression of a pool of target mRNAs common with EIF4E
  • represses target expression and oncogenic transformation, in direct contrast to EIF4E, which stimulates these processes
  • is, unexpectedly, a tumor suppressor and that it requires its atypical mode of cap recognition for this function
  • EIF4E, EIF4E2, and EIF4E3, are essential for translation initiation
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the EIF4F complex
  • INTERACTION
    DNA
    RNA
  • recognizes and bins to the 7-methylguanosine containing mRNA cap during an early step in the initiation of protein synthesis
  • small molecule
    protein
  • interacting with EIF4G1
  • MKNK1, MKNK2, can modulate oncogenic translation by regulating EIF4E-EIF4E3 levels and activity in diffuse large B-cell lymphoma (DLBCL)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS