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FLASH GENE
Symbol PRMT3 contributors: - updated : 04-11-2006
HGNC name protein arginine methyltransferase 3
HGNC id 30163
Location 11p15.1      Physical location : 20.409.075 - 20.530.877
Synonym name
  • heterogeneous nuclear ribonucleoprotein methyltransferase-like 3
  • HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae)
  • Synonym symbol(s) HRMT1L3
    DNA
    TYPE functioning gene
    STRUCTURE 121.00 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390098 11 similar to G protein-coupled receptor MRGX1 LOC390099 11 similar to G protein-coupled receptor SNSR2 MRGX1 11p15.1 G protein-coupled receptor MRGX1 LOC390100 11 similar to G protein-coupled receptor MRGX3 LOC390101 11 similar to G protein-coupled receptor SNSR1 MRGX2 11p15.1 G protein-coupled receptor MRGX2 HIP14L 11p15.1 G protein-coupled receptor MRGX2 CSRP3 11p15.1 cysteine and glycine-rich protein 3 (cardiac LIM protein) FLJ23311 11p15.1 FLJ23311 protein LOC390102 11 similar to Proliferating cell nuclear antigen (PCNA) (Cyclin) NAV2 11p15.1 neuron navigator 2 LOC120237 11p15.1 similar to Homeobox protein DBX1 HTATIP2 11p15.1 HIV-1 Tat interactive protein 2, 30kDa PRMT3 11p15.1 protein arginine N-methyltransferase 3(hnRNP methyltransferase S. cerevisiae)-like 3 SLC6A5 11p15.2-p15.1 solute carrier family 6 (neurotransmitter transporter, glycine), member 5 NELL1 11p15.1-p15.2 NEL-like 1 (chicken)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Respiratoryrespiratory tractlarynx  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C2H2-type zinc finger at the N-terminus
  • zinc-finger domain is necessary and sufficient for binding to RPS2
  • mono polymer homomer , monomer , dimer
    HOMOLOGY
    Homologene
    FAMILY protein arginine n-methyltransferase family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text only type I enzyme that is restricted to the cytoplasm
    basic FUNCTION
  • ribosomal protein methyltransferase that affects the cellular level of ribosomal subunits
  • regulating ribosome biosynthesis at a stage beyond pre-rRNA processing
  • catalysing the formation of asymmetric dimethylarginine
  • implicated in ribosomal function and in the regulation of protein synthesis
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with RPS2
    cell & other
    REGULATION
    inhibited by N-ethylmaleimide and high concentrations of zinc chloride
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS