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FLASH GENE
Symbol FEZF2 contributors: mct - updated : 10-09-2015
HGNC name FEZ family zinc finger 2
HGNC id 13506
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain with homology to the canonical engrailed repressor motif
  • a KRAB domain
  • C-terminal DNA binding domain containing six C2H2 zinc-finger repeats
    • HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • transcriptional repressor, required for the differentiation of projection neurons in cortical layer 5
  • is essential for specification of the subcerebral projection neurons in the neocortex
  • FEZF1 and FEZF2 control likely the rostro-caudal patterning of the diencephalon
  • FEZF1 and FEZF2 bind to and directly repress the promoter activity of HES5
  • FEZF1 and FEZF2 control differentiation of neural stem cells by repressing HES5 and, in turn, by derepressing neurogenin 2 in the forebrain
  • playing a critical role in layer- and neuronal subtype-specific patterning of cortical axonal projections and dendritic morphologies
  • required for the birth and specification of corticospinal motor neurons
  • directs the differentiation of corticofugal neurons from striatal progenitors
  • conserved gene critical for vertebrate forebrain development
  • FEZF1 and FEZF2, regulate the identity of main olfactory epithelium (MOE) sensory neurons and are essential for the survival of vomeronasal organ (VNO), neurons respectively
  • is important for early development of the posterior hypothalamus
  • is required for the development of excitatory neurons and nuclear morphology in the lateral and basolateral nuclei
  • FEZF1 and FEZF2 as important regulators of olfactory system development and sensory neuron identity
  • controlling neurogenesis and cell fate in the developing mammalian nervous system
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BCL11B is a major downstream effector of FEZF2 in regulating the extension of axons toward subcortical targets and can rescue the axonal phenotype of FEZF2 mutants
  • TBR1 is a direct transcriptional repressor of FEZF2 and a negative regulator of corticospinal tract formation that restricts the laminar origin of corticospinal axons specifically to L5
  • axon guidance receptor EPHB1 is a target of FEZF2 necessary to execute the ipsilateral extension of the corticospinal tract
    • cell & other
    REGULATION
    Other regulated by SOX5 and TBR1 (both SOX5 and TBR1 are required in the regulation of FEZF2 transcription)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate for evaluation in human microcephaly
    • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Fezf2(-/-) neurons adopt the fate of callosal projection neurons as assessed by their axonal projections, electrophysiological properties, and acquisition of Satb2 expression