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FLASH GENE

Symbol

FMNL3

contributors: mct - updated : 01-03-2014

HGNC name	formin-like 3
HGNC id	23698

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Danio rerio Fetal Lymphoid/Immune lymph node       highly   spleen       highly   thymus       highly

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Danio rerio Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one FH2 domain, promoting filament nucleation and influencing elongation through interaction with the barbed end, but is a poor nucleator , and possesses properties not shared by FMNL1 that allow it to generate filopodia
	one GBD/FH3 domain
	C-terminal non-FH2 AAs of FMNL3 are potentially required to stabilize the filament nucleus , and contains a WH2-like sequence that binds filament barbed ends and monomers, whose mutation disrupts monomer binding and inhibition of filament elongation

secondary structure

two adjacent aliphatic AAs within the predicted alpha-helix but does not have a leucine as the third aliphatic residue, although an alanine might functionally substitute to some degree

conjugated

PhosphoP

HOMOLOGY

interspecies

homolog to murine Fmnl3 (96.7pc)

Homologene

FAMILY

formin homology family

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	may be implicated in polarity control, invasion, migration, or metastasis through regulation of the Rho-related signaling pathway
	actin assembly factor that accelerate filament nucleation then remain on the elongating barbed end and modulate filament elongation
	influences actin dynamics and promotes filopodia formation
	crucial regulator of endothelial cell elongation during angiogenesis
	is required for microtubule alignment during angiogenic morphogenesis
	is a new regulator of endothelial microtubules during angiogenesis and is required for the conversion of quiescent ECs into their elongated angiogenic forms
	FMNL2 and FMNL3, are members of the formin family of proteins, were associated mainly with the plasma membrane and induced significant cellular morphological changes
	protein N-myristoylation plays critical roles in the cellular morphological changes induced by FMNL2 and FMNL3
	actin-assembly factor that act in a variety of actin-based processes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

RHOC promotes polarized migration through FMNL3 by restricting lamellipodial broadening

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS