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FLASH GENE
Symbol FMNL3 contributors: mct - updated : 01-03-2014
HGNC name formin-like 3
HGNC id 23698
Location 12q13.12      Physical location : 50.031.723 - 50.101.197
Synonym name
  • WW domain binding protein 3
  • formin homology 2 domain-containing protein 3
    • Synonym symbol(s) MGC45819, WBP3, KIAA2014, FLJ45265, DKFZp762B245, FHOD3, FRL2
    DNA
    TYPE functioning gene
    STRUCTURE 69.47 kb     26 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 11192 - 1027 - 2003 12684686
  • isoform 1
    • 25 - 11039 - 976 - 2003 12684686
  • isoform 2
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Danio rerioFetal
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Danio rerioFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one FH2 domain, promoting filament nucleation and influencing elongation through interaction with the barbed end, but is a poor nucleator , and possesses properties not shared by FMNL1 that allow it to generate filopodia
  • one GBD/FH3 domain
  • C-terminal non-FH2 AAs of FMNL3 are potentially required to stabilize the filament nucleus , and contains a WH2-like sequence that binds filament barbed ends and monomers, whose mutation disrupts monomer binding and inhibition of filament elongation
    • secondary structure
  • two adjacent aliphatic AAs within the predicted alpha-helix but does not have a leucine as the third aliphatic residue, although an alanine might functionally substitute to some degree
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Fmnl3 (96.7pc)
    Homologene
    FAMILY
  • formin homology family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be implicated in polarity control, invasion, migration, or metastasis through regulation of the Rho-related signaling pathway
  • actin assembly factor that accelerate filament nucleation then remain on the elongating barbed end and modulate filament elongation
  • influences actin dynamics and promotes filopodia formation
  • crucial regulator of endothelial cell elongation during angiogenesis
  • is required for microtubule alignment during angiogenic morphogenesis
  • is a new regulator of endothelial microtubules during angiogenesis and is required for the conversion of quiescent ECs into their elongated angiogenic forms
  • FMNL2 and FMNL3, are members of the formin family of proteins, were associated mainly with the plasma membrane and induced significant cellular morphological changes
  • protein N-myristoylation plays critical roles in the cellular morphological changes induced by FMNL2 and FMNL3
  • actin-assembly factor that act in a variety of actin-based processes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RHOC promotes polarized migration through FMNL3 by restricting lamellipodial broadening
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS