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FLASH GENE

Symbol

ATG16L1

contributors: mct - updated : 10-07-2017

HGNC name	ATG16 autophagy related 16-like 1 (S. cerevisiae)
HGNC id	21498

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Crohn disease to development of hepatocellular carcinoma (HCC)

Variant & Polymorphism SNP	increasing the risk of Crohn disease
	ATG16L1 polymorphism associated with an excessive production of IL1B and IL6, which may explain the effects of this polymorphism on the inflammatory process in Crohn disease
	ATG16L1 rs4663402 significantly associated with HCC risk

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS