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FLASH GENE

Symbol

ATG16L1

contributors: mct - updated : 10-07-2017

HGNC name	ATG16 autophagy related 16-like 1 (S. cerevisiae)
HGNC id	21498

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_030803 18 - 3411 NP_110430 - 607 colocalised with the lysosome within the cells, and with the mitochondria 2013 23512522 isoform 1, ATG16L1-1 contains the complete sequence NM_017974 17 - 3354 NP_060444 - 588 colocalised with the lysosome within the cells 2013 23512522 isoform 2, ATG16L1-2 lacks all of exon 8 NM_198890 - - 2922 NP_942593 - 444 - 2013 23512522 isoform 3, ATG16L1-6 NM_001190267 - - 3407 NP_001177196 - 491 - 2013 23512522 isoform 5, ATG16L1-5 NM_001190266 - - 3409 NP_001177195 - 523 . colocalised with the lysosome within the cells, and with the mitochondria 2013 23512522 isoform 4, ATG16L1-3 lacking the coiled-coil domain

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Endocrine neuroendocrine pituitary     highly Lymphoid/Immune thymus       highly Nervous nerve       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal APG16 domain consisting of coiled-coil domain involved in the process of autophagy
	and a tryptophan-aspartic acid (WD) repeat domain, involved in the process of autophagy
	a short domain the FIP200-binding domain (FBD)
	a motif with eight WD repeats, at the C-terminus

mono polymer

homomer , oligo

HOMOLOGY

interspecies

ortholog to murine Atg16l1

Homologene

FAMILY

WD repeat ATG16 family

CATEGORY

transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,lysosome
text	localized to preautophagosomal structure

basic FUNCTION	playing an essential role in autophagy
	involved in the membrane targeting of APG5L
	have a potential role within the intestinal epithelium by selective effects on the cell biology and specialized regulatory properties of Paneth cells
	regulates not only autophagy in all cell types, but also secretion from dense-core vesicles, presumably by acting as a Rab33A effector, in particular cell types

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component	part of either the minor and major complexes respectively composed of 4 sets of APG12L-APG5L and APG16L (400 kDa) or 8 sets of APG12L-APG5L and APG16L (800 kDa)
	ATG16L1 and NOD2 are components of an autophagy-mediated antibacterial pathway that is altered in a cell- and function-specific manner by Crohn disease-associated mutations
	is a key component of an E3-like ATG12-ATG5-ATG16L1 protein complex that catalyzes conjugation of the MAP1LC3 protein to lipids, thus controlling autophagic vesicle formation and expansion

INTERACTION

DNA

RNA

small molecule

protein	interacting with APG5L
	direct interaction between ATG5 and ATG16L1 is crucial to the performance of their roles in autophagy
	functional link between NOD2 and ATG16L1, which are encoded by two of the most important genes associated with Crohn disease
	interacts with the small GTPase RAB33A
	interaction between RB1CC1 and ATG16L1, essential components of the ULK1 and ATG5 complexes, respectively
	NOD1 CARD binds ubiquitin (Ub), in addition to directly binding its downstream targets receptor-interacting protein kinase 2 (RIPK2) and autophagy-related protein 16-1 (ATG16L1)
	endogenous TMEM59 interacts with ATG16L1 and mediates autophagy in response to Staphylococcus aureus infection
	during process of induced autophagy, the ATG12-ATG5 conjugate requires 2 different binding partners, ATG16L1 for autophagosome elongation and TECPR1 for lysosomal fusion
	TECPR1 and ATG16L1 share the same binding site on ATG5 (swapping of interaction partners with ATG5 for autophagosome maturation)
	C3 interacts with ATG16L1, which is essential for autophagy
	interface between WIPI2 and ATG16L1 mediates autophagosome formation under starvation conditions

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Crohn disease to development of hepatocellular carcinoma (HCC)

Variant & Polymorphism SNP	increasing the risk of Crohn disease
	ATG16L1 polymorphism associated with an excessive production of IL1B and IL6, which may explain the effects of this polymorphism on the inflammatory process in Crohn disease
	ATG16L1 rs4663402 significantly associated with HCC risk

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS