Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ARHGEF19 contributors: mct - updated : 24-01-2011
HGNC name Rho guanine nucleotide exchange factor (GEF) 19
HGNC id 26604
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DH-PH domain
  • a DBL homology (DH) interacting with N-terminal helices to exclude and prevent activation of Rho GTPases
  • a C-terminal SH3 domain
    • HOMOLOGY
    interspecies homolog to murine Arhgef19
    Homologene
    FAMILY Dbl-family proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text preferentially localized at the plasma membrane
    basic FUNCTION
  • activating RHOA, CDC42, and RAC1
  • may be involved in the development and functions of intestine, liver, heart and kidney
  • regulating adipogenesis through DNA methylation change
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the Wnt-PCP pathway that connects Dishevelled to Rho activation
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by tyrosine phosphorylation of a blocking helix
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS