Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

ARSI

contributors: mct - updated : 20-11-2018

HGNC name	arylsulfatase family member I
HGNC id	32521

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SPG66 spastic paraplegia-66
Location	5q32      Physical location : 149.675.908 - 149.682.525
Genatlas name	arylsulfatase I
Synonym name	hypothetical protein LOC340075
Synonym symbol(s)	FLJ16069, ASI, SPG66
EC.number	3.1.6.-

DNA

TYPE	functioning gene
STRUCTURE	6.62 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001012301 2 - 3191 NP_001012301 64 569 - 2009 19262745

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Epithelial barrier lining retinal pigment epithelium (RPE)   highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY

sulfatase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	may be a secreted sulfatase and may function in the extracellular space
	function in the gene regulatory network of early development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	one calcium ion per subunit

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPG66

Susceptibility

Variant & Polymorphism

Candidate gene	candidate gene causing inherited eye diseases
Marker
Therapy target

ANIMAL & CELL MODELS