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FLASH GENE
Symbol DND1 contributors: mct - updated : 11-07-2011
HGNC name dead end homolog 1 (zebrafish)
HGNC id 23799
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two RRM (RNA recognition motif) domains
  • a single-strand RNA-binding domain in the N-terminus
    • HOMOLOGY
    interspecies ortholog to rattus Dnd1_predicted
    ortholog to murine Dnd1
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may play a role during primordial germ cell (PGC) development
  • role of DND1 in protecting certain mRNAs from miRNA-mediated repression
  • essential for maintaining the viability of germ cells
  • able to bind to the 3prime-untranslated region (UTR) of messenger RNAs (mRNAs) to displace micro-RNA (miRNA) interaction with mRNA
  • possible role of DND1-APOBEC3 interaction in modulating miRNA-mediated mRNA repression
  • can potentially regulates mitotic arrest in male germ cells through translational regulation of cell cycle genes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacts specifically with APOBEC3(APOBEC3 interacts with cellular RNA-binding proteins and to mRNA to inhibit miRNA-mediated repression of mRNA, and interaction of DND1 and APOBEC3 could be one mechanism for maintaining viability of germ cells and for preventing germ cell tumor development)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to testicular germ cell tumors (rare variant)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • homozygous nonsense mutation (Ter) in murine Dnd1 (Dnd1(Ter/Ter)) results in a significant early loss of primordial germ cells (PGCs) prior to colonization of the gonad in both sexes