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FLASH GENE

Symbol

DND1

contributors: mct - updated : 11-07-2011

HGNC name	dead end homolog 1 (zebrafish)
HGNC id	23799

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Endocrine thyroid         Reproductive female system placenta       Skin/Tegument skin

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two RRM (RNA recognition motif) domains
	a single-strand RNA-binding domain in the N-terminus

HOMOLOGY

interspecies	ortholog to rattus Dnd1_predicted
	ortholog to murine Dnd1

Homologene

FAMILY

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	may play a role during primordial germ cell (PGC) development
	role of DND1 in protecting certain mRNAs from miRNA-mediated repression
	essential for maintaining the viability of germ cells
	able to bind to the 3prime-untranslated region (UTR) of messenger RNAs (mRNAs) to displace micro-RNA (miRNA) interaction with mRNA
	possible role of DND1-APOBEC3 interaction in modulating miRNA-mediated mRNA repression
	can potentially regulates mitotic arrest in male germ cells through translational regulation of cell cycle genes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , reproduction/sex

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

binding

small molecule

protein

interacts specifically with APOBEC3(APOBEC3 interacts with cellular RNA-binding proteins and to mRNA to inhibit miRNA-mediated repression of mRNA, and interaction of DND1 and APOBEC3 could be one mechanism for maintaining viability of germ cells and for preventing germ cell tumor development)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to testicular germ cell tumors (rare variant)

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

homozygous nonsense mutation (Ter) in murine Dnd1 (Dnd1(Ter/Ter)) results in a significant early loss of primordial germ cells (PGCs) prior to colonization of the gonad in both sexes