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FLASH GENE
Symbol ALG14 contributors: mct - updated : 17-01-2015
HGNC name asparagine-linked glycosylation 14 homolog (yeast)
HGNC id 28287
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region of ALG14 is required for direct interaction with ALG7
  • C-terminal three AAs of ALG14 are required for maintaining the integrity of ALG13/ALG14 complex, and this depends on their hydrophobicity
    • secondary structure
  • conserved alpha-helix involved in the second membrane association site that contributes to an integral interaction and protein stability
    • HOMOLOGY
    interspecies homolog to murine Alg14
    Homologene
    FAMILY
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • concentrated at the muscle motor endplates
  • ALG14 recruits cytosolic ALG13 to the ER membrane through interaction between their C-termini
    • basic FUNCTION
  • may function as a membrane anchor that recruits ALG13 to the cytosolic face of the ER
  • membrane protein that recruits the soluble ALG13 catalytic subunit from the cytosol to the face of the endoplasmic reticulum (ER) membrane where this reaction occurs
  • second step of eukaryotic N-linked glycosylation in endoplasmic reticulum is catalyzed by an UDP-N-acetylglucosamine transferase that is comprised of two subunits, ALG13 and ALG14
  • organizes the formation of a multiglycosyltransferase complex involved in initiation of lipid-linked oligosaccharide biosynthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between ALG13 and 14 is crucial for UDP-GlcNAc transferase activity, so formation of the ALG13/14 complex is likely to play a key role in the regulation of N-glycosylation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMSAL14
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS