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FLASH GENE
Symbol CLEC4A contributors: SGE/npt - updated : 23-03-2010
HGNC name C-type lectin domain family 4, member A
HGNC id 13257
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an ITIM motif (immunoreceptor tyrosine-based inhibitory motifs)
  • a C-type lectin domain
  • a single carbohydrate recognition domain (CRD)
  • a double cysteine motif at the start of the lectin domain
  • a potential N-glycosylation site
  • a 49-aminoacid intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM) proximal to the N terminus
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
  • type II membrane protein
    • basic FUNCTION
  • may be involved in regulating immune reactivity
  • may play a role in modulating dendritic cells (DC) differentiation and/or maturation
  • may be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation
  • APC receptor that is endocytosed in a clathrin-dependent manner and inhibits TLR8-mediated cytokine production (Meyer-Wentrup 2009)
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS immunity/defense
    text antimicrobial humoral response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • sugar
    • protein
  • PTPN6 via its ITIM motif (Huang 2001)
  • lectin
    • cell & other
  • ligand for HIV1, participating in viral capture and transmission (Lambert 2008)
    • REGULATION
    activated by TP53
    repressed by IFN-gamma (Ronninger 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • polymorphism is associated with rheumatoid arthritis (Ronninger 2008, Lorentzen 2007)
    • Candidate gene
    Marker
    Therapy target
  • targeting CLEC4A can modulate plasmacytoid dendritic cell function and may be applied in disease prevention and treatment, inhibiting IFN-alpha production (Meyer-Wentrup 2008)
    • ANIMAL & CELL MODELS