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FLASH GENE
Symbol CLEC4A contributors: SGE/npt - updated : 23-03-2010
HGNC name C-type lectin domain family 4, member A
HGNC id 13257
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 1284 27 237 peripheral blood leukocytes, spleen, lymph node, bone marrow Bates (1999)
  • isoform 1
  • a single CRD, a double-cysteine motif at the strat of the lectin domain, a potential N-glycosylation site and an ITIM
  • 5 splicing 1185 23 204 epxression is up-regulated by agonists of neutrophils GM-CSF, IL-3, IL-4 and IL-13 Huang (2001)
  • also known as C-type lectin DDB27 short form
  • isoform 2, missing the transmembrane domain compared to isoform 1
  • 5 splicing 1167 23 198 - Huang (2001)
  • also known as LLIRv1
  • isoform 3, missing the transmembrane domain compared to isoform 1
  • 4 splicing 1068 19 165 - Huang (2001)
  • also known as LLIRv2
  • isoform 4, missing a region thought to be responsible for oligomerization compared to isoform 1
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
     spleen   moderately
     thymus   lowly
     tonsils    
    Nervousspinal cord   lowly
    Respiratorylung   moderately
     respiratory tracttrachea  lowly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines immature and mature monocyte-derived dendritic cells, monocytes, macrophages, B-cells, myeloid and plasmacytoid dendritic cells (Meyer-Wentrup 2009)
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ITIM motif (immunoreceptor tyrosine-based inhibitory motifs)
  • a C-type lectin domain
  • a single carbohydrate recognition domain (CRD)
  • a double cysteine motif at the start of the lectin domain
  • a potential N-glycosylation site
  • a 49-aminoacid intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM) proximal to the N terminus
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
  • type II membrane protein
  • basic FUNCTION
  • may be involved in regulating immune reactivity
  • may play a role in modulating dendritic cells (DC) differentiation and/or maturation
  • may be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation
  • APC receptor that is endocytosed in a clathrin-dependent manner and inhibits TLR8-mediated cytokine production (Meyer-Wentrup 2009)
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS immunity/defense
    text antimicrobial humoral response
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • sugar
  • protein
  • PTPN6 via its ITIM motif (Huang 2001)
  • lectin
  • cell & other
  • ligand for HIV1, participating in viral capture and transmission (Lambert 2008)
  • REGULATION
    activated by TP53
    repressed by IFN-gamma (Ronninger 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • polymorphism is associated with rheumatoid arthritis (Ronninger 2008, Lorentzen 2007)
  • Candidate gene
    Marker
    Therapy target
  • targeting CLEC4A can modulate plasmacytoid dendritic cell function and may be applied in disease prevention and treatment, inhibiting IFN-alpha production (Meyer-Wentrup 2008)
  • ANIMAL & CELL MODELS