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FLASH GENE
Symbol INTS1 contributors: npt/mct/pgu - updated : 02-09-2009
HGNC name integrator complex subunit 1
HGNC id 24555
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
Homologene
FAMILY
  • integrator subunit 1 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    text predominantly nuclear localization
    basic FUNCTION
  • is recruited to the U1 and U2 snRNA genes and mediates the snRNA's 3' end processing
  • the integrator complex mediates RNA polymerase-II-dependent transcription
  • largest subunit of the integrator complex, which mediates U1 and U2 snRNA 3'-end processing
  • play non-redundant roles in the cell such as the formation of a scaffold for the assembly of the integrator complex
  • INTS1, TRRAP, and SKIV2L2 are implicated in distinct steps of thymus development
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the RNA polymerase II complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stably associated with RNAPII
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    developing KIAA1440(-/-) mouse embryo in a pure ICR background arrests its growth at the early blastocyst stage, whereas the majority of the KIAA1440(-/-) embryos of mixed genetic backgrounds do not progress beyond the morula stage, approximately 0.5 days earlier