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FLASH GENE
Symbol NRK contributors: mct - updated : 28-06-2012
HGNC name Nik related kinase
HGNC id 25391
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Nrk
Homologene
FAMILY
  • Ser/Thr protein kinase family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as an activator of the JNK pathway
  • may be involved in the regulation of actin cytoskeletal organization in skeletal muscle cells through cofilin phosphorylation
  • required for placental development
  • does not regulate the levels of progesterone and estrogen
  • NRK-mediated signaling may potentially operate in labor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • cofilin is likely to be a direct substrate of NRK
  • NRK and ESX1 may participate in the same signaling pathway that regulates placental development
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    reproductionpregnancy 
    serves as a potential target to therapeutically control human labor
    ANIMAL & CELL MODELS
  • Pregnant mice exhibited a severe defect in labor when all the fetuses and placentas were Nrk-null in utero