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FLASH GENE

Symbol

NRK

contributors: mct - updated : 28-06-2012

HGNC name	Nik related kinase
HGNC id	25391

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	136.07 kb     29 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_198465 29 - 8080 NP_940867 - 1582 - 2003 12837278

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       predominantly Reproductive female system ovary     moderately   female system placenta     highly Urinary kidney       highly Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular striatum skeletal     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	placenta
	specifically expressed in the spongiotrophoblast layer, a fetus-derived region of the placenta
	in the fetal skeletal muscle

IMPRINTING	paternally
text	paternally derived NRK is preferentially but incompletely inactivated in placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Nrk

Homologene

FAMILY

Ser/Thr protein kinase family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION	acting as an activator of the JNK pathway
	may be involved in the regulation of actin cytoskeletal organization in skeletal muscle cells through cofilin phosphorylation
	required for placental development
	does not regulate the levels of progesterone and estrogen
	NRK-mediated signaling may potentially operate in labor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein	cofilin is likely to be a direct substrate of NRK
	NRK and ESX1 may participate in the same signaling pathway that regulates placental development

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed reproduction pregnancy   serves as a potential target to therapeutically control human labor

ANIMAL & CELL MODELS

Pregnant mice exhibited a severe defect in labor when all the fetuses and placentas were Nrk-null in utero