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FLASH GENE
Symbol MRGPRD contributors: mct - updated : 07-12-2011
HGNC name MAS-related GPR, member D
HGNC id 29626
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to rattus Mrgprd
ortholog to murine Mrgprd
intraspecies homolog to MAS1
Homologene
FAMILY
  • G-protein coupled receptor 1 family
  • Mas subfamily
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral membrane protein
  • localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine
  • sensory neurons expressing the MRGPRD receptor are known to innervate the outermost living layer of the epidermis, the stratum granulosum
    • basic FUNCTION
  • may regulate nociceptor function and/or development, including the sensation or modulation of pain
  • functioning as a specific membrane receptor for beta-alanine
  • acting as a rhodopsin-like receptor
  • marks a distinct subset of sensory neurons that transmit polymodal nociceptive information from the skin epidermis to the substantia gelatinosa (SG, lamina II) of the spinal cord
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between MRGPRD and KCNQ2 that contributes to an increase in excitability of dorsal root ganglion neurons and thus may enhance the signaling of primary afferent nociceptive neurons
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS