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FLASH GENE

Symbol

MRGPRD

contributors: mct - updated : 07-12-2011

HGNC name	MAS-related GPR, member D
HGNC id	29626

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q13.3      Physical location : 68.747.490 - 68.748.455
Synonym symbol(s)	MRGD, TGR7

DNA

TYPE	functioning gene
STRUCTURE	0.97 kb     1 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_198923 1 - 966 - 321 - 2004 15037633

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous spinal cord sensory ganglia       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to rattus Mrgprd
	ortholog to murine Mrgprd

intraspecies

homolog to MAS1

Homologene

FAMILY	G-protein coupled receptor 1 family
	Mas subfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral membrane protein
	localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine
	sensory neurons expressing the MRGPRD receptor are known to innervate the outermost living layer of the epidermis, the stratum granulosum

basic FUNCTION	may regulate nociceptor function and/or development, including the sensation or modulation of pain
	functioning as a specific membrane receptor for beta-alanine
	acting as a rhodopsin-like receptor
	marks a distinct subset of sensory neurons that transmit polymodal nociceptive information from the skin epidermis to the substantia gelatinosa (SG, lamina II) of the spinal cord

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

interaction between MRGPRD and KCNQ2 that contributes to an increase in excitability of dorsal root ganglion neurons and thus may enhance the signaling of primary afferent nociceptive neurons

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS