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FLASH GENE
Symbol LCN6 contributors: mct - updated : 16-10-2023
HGNC name lipocalin 6
HGNC id 17337
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a predicted 20-amino acid signal peptide
  • multiple phosphorylation sites
    • secondary structure
  • beta-barrel structure
    • HOMOLOGY
    interspecies ortholog to rattus Lcn6
    ortholog to murine Lcn6
    Homologene
    FAMILY
  • lipocalin family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    text
  • secreted
  • located on the head and tail of spermatozoa with the highest concentration on the post-acrosomal region of the head, where it appears aggregated into large patches
    • basic FUNCTION
  • may play a role in male fertility
  • acting as a prostaglandin-D synthase
  • LCN6 is a novel lipocalin closely related to LCN8 and these genes are likely products of gene duplication events that predate rodent-primate divergence
  • predominant expression in the epididymis and location on sperm surface are consistent with a role for LCN6 in male fertility
  • may function as a transporter to carry ligands in the epididymal channel
  • LCN6, LCN8, LCN9, LCN10 epididymal secretory proteins are likely involved in ADAM3 maturation and acquisition of sperm fertilizing ability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • prostaglandin metabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS