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FLASH GENE
Symbol MUTED contributors: mct/npt - updated : 08-01-2007
HGNC name muted homolog (mouse)
HGNC id 18561
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil forming protein
  • a possible vacuolar targeting motif (TLPK)
    • HOMOLOGY
    interspecies ortholog to murine Muted
    ortholog to rattus Muted_predicted
    ortholog to chicken MUTED
    Homologene
    FAMILY
  • Muted family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • involved in the development of lysosome-related organelles, such as melanosomes and platelet-dense granules
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of lysosome-related organelles complex-1 (BLOC-1), with MUTED, PLDN, CNO, SNAPAP, BLOC1S1, BLOC1S2, and BLOC1S3, a ubiquitously expressed multisubunit protein complex required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • pallidin
  • dystrobrevin binding protein 1
  • CNO/cappuccino
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mouse model for Hermansky-Pudlak Syndrome