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FLASH GENE
Symbol MUTED contributors: mct/npt - updated : 08-01-2007
HGNC name muted homolog (mouse)
HGNC id 18561
Location 6p25.1-p24.3      Physical location : 8.014.216 - 8.064.647
Synonym symbol(s) MU, dJ303A1.3, DKFZp686E2287
DNA
TYPE functioning gene
STRUCTURE 50.43 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text some transcripts of the downstream gene TXNDC5 overlap this gene, but they do not contain an open reading frame for this gene
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2282 21.5 187 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinelarge intestinecolon highly
Endocrineadrenal gland    
 neuroendocrinepituitary   
Reproductivemale systemprostate   
Skin/Tegumentskin   predominantly
cell lineage
cell lines
fluid/secretion lymph
at STAGE
physiological period pregnancy
Text umbilical cord
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a coiled-coil forming protein
  • a possible vacuolar targeting motif (TLPK)
  • HOMOLOGY
    interspecies ortholog to murine Muted
    ortholog to rattus Muted_predicted
    ortholog to chicken MUTED
    Homologene
    FAMILY
  • Muted family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • involved in the development of lysosome-related organelles, such as melanosomes and platelet-dense granules
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of lysosome-related organelles complex-1 (BLOC-1), with MUTED, PLDN, CNO, SNAPAP, BLOC1S1, BLOC1S2, and BLOC1S3, a ubiquitously expressed multisubunit protein complex required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • pallidin
  • dystrobrevin binding protein 1
  • CNO/cappuccino
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mouse model for Hermansky-Pudlak Syndrome