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FLASH GENE
Symbol TRIM50 contributors: mct - updated : 17-03-2017
HGNC name tripartite motif-containing 50
HGNC id 19017
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-type zinc finger
  • a B box-type zinc finger
  • a coiled-coil domain
  • a B30.2/SPRY domain
    • HOMOLOGY
    interspecies homolog to rattus Trim50 (87.6 pc)
    homolog to murine Trim50 (89.1 pc)
    intraspecies homolog to TRIM72
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text
  • TRIM50 resides likely in the cell interior canaliculi generated by tubulovesicular fusion during the stimulated phase
    • basic FUNCTION
  • acting as a E3-ubiquitin-protein ligase
  • catalyzing uquitination in presence of UBE2E2 through the Ring domain
  • TRIM50 localizes to and promotes the recruitment and aggregation of polyubiquitinated proteins to the aggresome
  • likely when the proteasome activity is impaired, TRIM50 fails to drive its substrates to the proteasome-mediated degradation, and promotes their storage in the aggresome for successive clearance
  • is likely involved in vesicular dynamics by sensing the phosphorylated state of phosphoinositol lipids
  • seems to play an essential role in tubulovesicular dynamics, promoting the formation of sophisticated canaliculi and microvilli during acid secretion in gastric parietal cells
  • TRIM50 and TRIM72 may exert similar biological roles in vesicular trafficking below the cell membrane in muscle and parietal cells, respectively
  • TRIM50 promotes the formation and clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction, a tubulin specific deacetylase that regulates microtubule-dependent aggresome formation
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • TRIM50 colocalizes, interacts with and increases the level of SQSTM1, a multifunctional adaptor protein implicated in various cellular processes including the autophagy clearance of polyubiquitinated protein aggregates
  • TRIM50 may share similar biological functions with TRIM72 in vesicular trafficking
  • EP300 and KAT2B are two TRIM50 acetyltransferases and the balance between ubiquitination and acetylation regulates TRIM50 degradation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) WBS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Trim50 knock-out mice retained normal histology in the gastric mucosa but exhibited impaired secretion of gastric acid