| basic FUNCTION
| acting as a transcriptional corepressor |
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required for nucleosome assembly during sperm nucleus decondensation |
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acting as an histone chaperone |
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involved in the formation of senescence-associated heterochromatin foci (SAHF) in skin fibroblasts |
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HIRA and ASF1A, play an important role in muscle differentiation by facilitating MYOD1 expression |
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involved in chromosome condensation depending on the ability of ASF1A to physically interact with its deposition substrate, histone H3, in addition to its cochaperone, HIRA  |
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replication-independent (RI) histone chaperone that is linked to transcription and various developmental processes |
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participates in MEF2A-mediated transcriptional activation |
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involved in both transcriptional activation and repression of target genes, implying that its activity may be regulated under various circumstances |
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may directly contribute to muscle-specific gene activation through MEF2A, MEF2D |
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acts as a scaffold to bring together UBN1, ASF1A, and CABIN1 into a quaternary complex |
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conserved histone chaperone required for regulation of chromatin structure |
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involved in cross-tolerance via regulation of stress-responsive gene expression |
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may stimulate or repress transcription via mediation of nucleosome states, depending on the situation |
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early and transient function of HIRA in response to DNA damage primes chromatin for later reactivation of transcription |
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histone chaperone HIRA plays a critical role in transcription recovery upon UVC damage and does so without significantly affecting the repair process per se |
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HIRA recruitment to damaged regions acts as a priming event making damaged chromatin prone for transcription restart once repair is complete |
