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FLASH GENE
Symbol HIKESHI contributors: mct - updated : 05-07-2017
HGNC name Hikeshi, heat shock protein nuclear import factor
HGNC id 26938
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal domain (NTD) consists of a jelly-roll/beta-sandwich fold structure which contains hydrophobic pockets involved in FG-Nup recognition
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to rattus loc293103
    Homologene
    FAMILY
  • OPI10 family
    • CATEGORY receptor nuclear
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • protects cells from heat shock-induced nuclear damage
  • HIKESHI-mediated nuclear import is essential for the attenuation and reversal of the thermal stress response in human cells
  • is a nuclear transport receptor required for cell survival after stress
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • mediates the nuclear import of the molecular chaperone HSP70
  • mediates heat-shock-induced nuclear import of 70&
    • 8197;kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins (FG-Nups), which are proteins in nuclear pore complexes (NPCs)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HLD13
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in late stage of clear cell renal cell carcinoma (ccRCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS