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FLASH GENE

Symbol

HIKESHI

contributors: mct - updated : 05-07-2017

HGNC name	Hikeshi, heat shock protein nuclear import factor
HGNC id	26938

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pancreas exocrine       moderately Nervous brain       highly Reproductive female system ovary     moderately   female system uterus     predominantly   male system prostate     moderately Skin/Tegument skin       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal domain (NTD) consists of a jelly-roll/beta-sandwich fold structure which contains hydrophobic pockets involved in FG-Nup recognition

mono polymer

homomer , dimer

HOMOLOGY

interspecies

ortholog to rattus loc293103

Homologene

FAMILY

OPI10 family

CATEGORY

receptor nuclear

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION	protects cells from heat shock-induced nuclear damage
	HIKESHI-mediated nuclear import is essential for the attenuation and reversal of the thermal stress response in human cells
	is a nuclear transport receptor required for cell survival after stress

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	mediates the nuclear import of the molecular chaperone HSP70
	mediates heat-shock-induced nuclear import of 70&
	8197;kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins (FG-Nups), which are proteins in nuclear pore complexes (NPCs)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HLD13

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in late stage of clear cell renal cell carcinoma (ccRCC)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS