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FLASH GENE

Symbol

CRB2

contributors: mct - updated : 29-05-2014

HGNC name	crumbs homolog 2 (Drosophila)
HGNC id	18688

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	deletion of Crb2 in the murine retina results in early retinal disorganization leading to severe and progressive retinal degeneration with a concomitant visual loss that mimics retinitis pigmentosa due to mutations in the CRB1 gene
	severe abnormalities appearing in Crb2-deficient mice embryos at late-gastrulation