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FLASH GENE

Symbol

DEFB109P1

contributors: shn - updated : 04-04-2011

HGNC name	defensin, beta 109, pseudogene 1
HGNC id	18090

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p23.1      Physical location : 12.250.792 - 12.257.874
Synonym name	defensin, beta 109
	Human beta-Defensin 9
Synonym symbol(s)	DEFB-9, DEFB109, DEFB109A, HBD9

DNA

TYPE	pseudogene
SPECIAL FEATURE
text	translation start site (ATG) in the upstream region is unknown
STRUCTURE	7.08 kb     1 Exon(s)

MAPPING

cloned

N

linked

N

status

provisional

Map	pter - D8S1695 - D8S1759 - DEFB109P1 - D8S552 - D8S1106 - qter

RNA

TRANSCRIPTS	type

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NR_024044 - - 189 HBD9 - - ocular surface epithelium, highly concentrated in superficial layers of corneal epithelium, conjunctiva, and limbus - 20375350

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Digestive intestine large intestine colon   lowly Homo sapiens   intestine small intestine     moderately Homo sapiens   liver       highly Homo sapiens Endocrine pancreas       highly Homo sapiens Lymphoid/Immune spleen       moderately Homo sapiens   thymus       lowly Homo sapiens Nervous brain       highly Homo sapiens Reproductive female system ovary     highly Homo sapiens   female system placenta     moderately Homo sapiens   male system prostate     lowly Homo sapiens   male system testis     highly Homo sapiens Respiratory lung       highly Homo sapiens Urinary kidney       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   lowly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a consensus six-cysteine motif

HOMOLOGY

Homologene

FAMILY

human beta-defensins

CATEGORY

SUBCELLULAR LOCALIZATION

basic FUNCTION	constitutively present in gingival keratinocytes and to be downregulated in response to Candida albicans
	may have a role in ocular surface epithelium defense against invading pathogens

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	host defense against microbial infection

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other	HBD9 expression is modulated in response to the activation of TLRs in corneal epithelial cells (
	HBD9 Expression is modulated by NOD2 in corneal epithelial cells (
	regulated by IL-1beta in corneal epithelial cells (

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS