basic FUNCTION
| may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations) |
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mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, |
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thereby playing an essential role in heme biosynthesis |
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functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts (Shaw 2006) |
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essential for heme and Fe/S cluster synthesis in erythroblasts and is required for primitive and definitive erythropoiesis (Chen 2009) |
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functions as an essential iron importer for the synthesis of mitochondrial heme and iron–sulfur clusters in erythroblasts (Chen 2009) |
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in erythroid cells, ferrous iron is imported into the mitochondrion by SLC25A37 |