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FLASH GENE
Symbol SLC22A18AS contributors: mct/npt - updated : 09-01-2009
HGNC name solute carrier family 22 (organic cation transporter), member 18 antisense
HGNC id 10965
DNA
TYPE functioning gene
STRUCTURE 12.76 kb     4 Exon(s)
regulatory sequence Promoter (CAAT box) (TATA box)
Binding site   hormone
text structure
  • dual promoters (P1 and P2) and both are devoid of consensus TATA and CCAAT boxes
  • expression of this gene was found to be methylation-dependent and histone acetylation-independent
  • P1 promoter harbors a putative Sp1 binding site, and Sp1 is the transactivator of the P1 promoter
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1565 - 253 - Bajaj (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     liver   predominantly
    Reproductivefemale systemplacenta   
     male systemprostate   
    Urinarykidney   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver, kidney predominantly
    IMPRINTING paternally
    text
  • imprinting of the paternal allele in five fetal tissues: brain, liver, placenta, kidneys and lungs
  • biallelic expression in adult breast tissue
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane segments protein
  • a large acidic cytoplasmic C terminal domain
    • HOMOLOGY
    Homologene
    FAMILY solute carrier family 22, organic cation
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text translated into a novel protein of 30 kDa with a cytoplasmic localization
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS