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FLASH GENE
Symbol TXNL4A contributors: mct - updated : 07-01-2015
HGNC name thioredoxin-like 4A
HGNC id 30551
Corresponding disease
BMKS Burn-McKeown syndrome
Location 18q23      Physical location : 77.732.868 - 77.748.532
Synonym name
  • DIM1 protein homolog
  • thioredoxin-like U5 snRNP protein U5-15kD
  • spliceosomal U5 snRNP-specific 15 kDa protein
    • Synonym symbol(s) DIM1, HsT161, TXNL4, U5-15kD, DIB1, SNRNP15
    DNA
    TYPE functioning gene
    STRUCTURE 15.68 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1415 - 142 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrinepancreas    
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemuterus   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to yeast Dib1
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text spliceosome complex
    basic FUNCTION
  • involved in pre-mRNA splicing, and participating in different multisubunit complexes and biological processes
  • besides its function in pre-mRNA splicing, is a peptidase and has autocleavage activity
    • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PQBP1 binds to TXNL4A via a continuous 23-AAs segment within its C-terminal domain
  • TXNL4A hydrophobic groove recognizes a YxxPxxVL motif in PQBP1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BMKS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS