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FLASH GENE
Symbol TXNDC17 contributors: mct - updated : 11-06-2021
HGNC name thioredoxin domain containing 17
HGNC id 28218
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two active site Cys residues in its WCPDC motif, which is comparable to the WCGPC motif of thioredoxin (Trx)
    • HOMOLOGY
    Homologene
    FAMILY
  • thioredoxin family
    • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • disulfide reductase modulating TNF-alpha signaling pathways
  • oxidoreductase activities of TXNDC17 complement those of TXN and must therefore be considered for the full understanding of enzymatic control of cellular thiols and nitrosothiols
  • TXNDC17 is likely a member of the thioredoxin system dedicated to the control of cellular redox signalling pathways
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TXN
  • DYNLL1 binds IkappaBalpha in a redox-dependent manner and thereby prevents its phosphorylation by IKK, and TXNDC17contributes to this inhibitory activity by maintaining DYNLL1 in a reduced state
  • inhibits the TNF-induced NFKB1 activation to a greater extent than TXN
  • DYNLL1 was identified as a new target of disulfide reductase activity of TXNDC17, and DYNLL1 was shown to bind IkappaBalpha in a redox-dependent manner, thereby preventing its phosphorylation by IKBKB
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS