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FLASH GENE
Symbol ARMC4 contributors: mct - updated : 05-10-2013
HGNC name armadillo repeat containing 4
HGNC id 25583
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 10 Armadillo repeat motifs (ARMs)
  • one HEAT repeat
    • HOMOLOGY
    interspecies homolog to drosophila gudu
    homolog to murine Armc4
    Homologene
    FAMILY
  • beta-catenin family
  • ARM super-family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text expressed in multiciliated airway cells
    basic FUNCTION
  • axonemal protein that is necessary for proper targeting and anchoring of outer dynein arms
  • functional role in the establishment of left-right asymmetry
  • ciliary protein required for correct axonemal docking and targeting of outer dynein arm components and/or complexes
  • Gudu and ARMC4 are a subfamily of Armadillo-repeat containing proteins that may have an evolutionarily conserved function in spermatogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TTC25 is essential for the assembly of all three known ODA- docking complex proteins, CCDC151, CCDC114, or ARMC4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICS24
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS