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FLASH GENE
Symbol ANKRD13C contributors: mct - updated : 18-06-2011
HGNC name ankyrin repeat domain 13C
HGNC id 25374
Location 1p31.1      Physical location : 70.724.685 - 70.820.417
Synonym symbol(s) dJ677H15.3, RP4-677H15.5, DKFZP566D1346, FLJ14998
DNA
TYPE functioning gene
STRUCTURE 92.86 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 5682 61 541 - 2010 20959461
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   predominantly
Lymphoid/Immunelymph node    
Nervousbrain    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ankyrin repeats and AAs 489498 of ANKRD13C are essential for its function
  • HOMOLOGY
    interspecies ortholog to rattus LOC312746
    Homologene
    FAMILY
  • ankyrin repeat family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • protein associated with the cytosolic side of ER membranes
  • peripheral membrane protein associated with the ER
  • basic FUNCTION
  • acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER
  • novel regulator of the biogenesis and trafficking of GPCRs through the biosynthetic pathway
  • can promote the biogenesis of GPR44 and its trafficking to the plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting partner for the prostaglandin D2 receptor
  • interaction between ANKRD13C and GPR44
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS