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FLASH GENE
Symbol ANGEL2 contributors: mct - updated : 26-10-2018
HGNC name angel homolog 2 (Drosophila)
HGNC id 30534
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved Mg2+-dependent nuclease domains shared by all members of the Exonuclease, Endonuclease, and Phosphatase (EEP) superfamily (
    • HOMOLOGY
    interspecies ortholog to murine D1Ertd396e
    Homologene
    FAMILY
  • CCR4/nocturin family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • ANGEL2 resides in the nucleus when exogenously expressed, while the majority of deadenylation reactions are thought to occur in the cytoplasm
    • basic FUNCTION
  • ANGEL1 and ANGEL2 are predicted to function as deadenylases, but there are some key differences between these proteins and the other CCR4 family members
  • ANGEL2 can not only function as a deadenylase but also as an RNA-binding protein to alter target gene expression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS