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FLASH GENE

Symbol

ANGEL2

contributors: mct - updated : 26-10-2018

HGNC name	angel homolog 2 (Drosophila)
HGNC id	30534

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_144567 9 - 4717 NP_653168 62.2 544 - 2007 17178830 NM_001300758 8 - 4391 NP_001287687 - 375 - 2007 17178830 NM_001300753 9 - 4642 NP_001287682 - 418 - 2007 17178830 NM_001300757 8 - 4395 NP_001287686 - 375 - 2007 17178830 NM_001300755 9 - 4740 NP_001287684 - 418 - 2007 17178830

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Homo sapiens Reproductive female system uterus cervix   predominantly   female system breast mammary gland

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conserved Mg2+-dependent nuclease domains shared by all members of the Exonuclease, Endonuclease, and Phosphatase (EEP) superfamily (

HOMOLOGY

interspecies

ortholog to murine D1Ertd396e

Homologene

FAMILY

CCR4/nocturin family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	ANGEL2 resides in the nucleus when exogenously expressed, while the majority of deadenylation reactions are thought to occur in the cytoplasm

basic FUNCTION	ANGEL1 and ANGEL2 are predicted to function as deadenylases, but there are some key differences between these proteins and the other CCR4 family members
	ANGEL2 can not only function as a deadenylase but also as an RNA-binding protein to alter target gene expression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS