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FLASH GENE
Symbol MTPAP contributors: mct - updated : 02-12-2010
HGNC name mitochondrial poly(A) polymerase
HGNC id 25532
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Papd1
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • nuclear-encoded mitochondrial poly(A) RNA polymerase, implicated in polyadenylation of mRNA, and essential for maintaining mitochondrial gene expression
  • MTPAP, PAPD4, PAPD5, ZCCHC6, ZCCHC11, and TUT1, were found to govern 3prime nucleotide addition to miRNAs in a miRNA-specific manner
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPAX4
    Susceptibility
    Variant & Polymorphism
    Candidate gene potential candidate gene for the extreme obesity
    Marker
    Therapy target
    ANIMAL & CELL MODELS