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FLASH GENE
Symbol OXTR contributors: mct/npt/pgu - updated : 09-06-2010
HGNC name oxytocin receptor
HGNC id 8529
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three N-glycosylation sites in its extracellular N-terminal domain
  • seven transmembrane segments (7TM) receptor
  • E/DRY motif involved not only in receptor activation but also in the promiscuity of G protein coupling
    • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY signaling hormone , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • oxytocin-oxytocin receptor system plays an important role in the uterus during parturition
  • might be involved in coordinating timely and appropriate proliferation and migration of the penile cells
  • exhibit promiscuous activity by coupling to both Galpha(q) and Galpha(i) G proteins to activate distinct signaling pathways
  • role of OXTR and the oxytocin signaling pathway in the etiology of autism
  • may be implicated in social cognition
  • central role of this receptor in the functionality of oxytocin
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to autism spectrum disorders (not play a major role)
  • to variation of the prosocial disposition.
    • Variant & Polymorphism SNP
  • SNP (rs53576) known to predict prosocial tendencies is signaled through display behavior that leads to reliable observer inferences of the target prosociality
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS