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FLASH GENE
Symbol AGPAT5 contributors: mct - updated : 20-09-2005
HGNC name 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
HGNC id 20886
Location 8p23.1      Physical location : 6.565.877 - 6.619.019
Synonym name
  • 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon
  • 1-acylglycerol-3-phosphate O-acyltransferase 5
  • Synonym symbol(s) LPAATE, 1-AGPAT5, LPAAT-epsilon, FLJ11210
    EC.number 2.3.1.51
    DNA
    TYPE functioning gene
    STRUCTURE 53.15 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 5535 - 364 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the HXXXXD motif
  • four conserved motifs (I–IV), whose invariant residues appear to be important for catalysis and/or substrate recognition
  • HOMOLOGY
    interspecies homolog to murine Agpat5
    Homologene
    FAMILY
  • 1-acyl-sn-glycerol-3-phosphate acyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • converting lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    phospholipid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS