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FLASH GENE
Symbol SIM2 contributors: mct - updated : 31-05-2015
HGNC name single-minded homolog 2 (Drosophila)
HGNC id 10883
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 stomach   highly
Reproductivefemale systemovary  highly
 male systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines glioblastoma cell line
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic helix-loop-helix (bHLH) juxtaposed to
  • a stretch of approximately 300 AA, termed the PAS (Per - ARNT - Sim) region
  • a NLS consisting of a cluster of basic amino acids with Pro and Tyr at the C-terminal
    • HOMOLOGY
    interspecies homolog to Drosophila (single-minded 2) Sim2
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • master regulator of fruit fly midline neurogenesis
  • involved in the development of midline cells in the central nervous system
  • MAD2L2 may mediate SIM2 function during development in CNS and thereby play a critical role in pathophysiological mechanisms in Down syndrome
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAD2L2 is a novel SIM2 binding protein
  • MAGED1 binds and positively regulates the transcriptional activity of family members SIM1, SIM2, NPAS4 and ARNT2, but does not interact with AHR, HIF1A and ARNT
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TRI21
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS