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FLASH GENE
Symbol AGPAT4 contributors: mct - updated : 19-09-2005
HGNC name 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
HGNC id 20885
Location 6q26      Physical location : 161.551.056 - 161.695.107
Synonym name
  • 1-acyl-sn-glycerol-3-phosphate acyltransferase delta
  • LPAAT-delta
  • 1-AGP acyltransferase 4
  • Synonym symbol(s) 1-AGPAT4, dJ473J16.2, LPAAT-delta, RP3-473J16.2
    EC.number 2.3.1.51
    DNA
    TYPE functioning gene
    STRUCTURE 144.05 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 7889 44 378 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Lymphoid/Immunespleen    
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • the HXXXXD motif
  • four conserved motifs (I–IV), whose invariant residues appear to be important for catalysis and/or substrate recognition )
  • HOMOLOGY
    Homologene
    FAMILY
  • 1-acyl-sn-glycerol-3-phosphate acyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • converting lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    glycerophospholipid
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS