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FLASH GENE
Symbol A4GNT contributors: mct - updated : 29-01-2009
HGNC name alpha-1,4-N-acetylglucosaminyltransferase
HGNC id 17968
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • glycosyltransferase sugar-binding region
  • DXD motif
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine A4gnt
    Homologene
    FAMILY
  • glycosyltransferase 32 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • catalyzing the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans
  • glycosyltransferase responsible for the biosynthesis of alpha1,4-GlcNAc-capped O-glycans
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene quantitative analysis of alpha4GnT mRNA expressed in the mononuclear cell fraction of peripheral blood will contribute to the detection of pancreatic cancer
    Marker
    Therapy target
    ANIMAL & CELL MODELS