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FLASH GENE
Symbol A4GNT contributors: mct - updated : 29-01-2009
HGNC name alpha-1,4-N-acetylglucosaminyltransferase
HGNC id 17968
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandular  
Muscularsmoothmuscularis mucosa (tractus digestif)   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • glycosyltransferase sugar-binding region
  • DXD motif
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine A4gnt
    Homologene
    FAMILY
  • glycosyltransferase 32 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • catalyzing the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans
  • glycosyltransferase responsible for the biosynthesis of alpha1,4-GlcNAc-capped O-glycans
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene quantitative analysis of alpha4GnT mRNA expressed in the mononuclear cell fraction of peripheral blood will contribute to the detection of pancreatic cancer
    Marker
    Therapy target
    ANIMAL & CELL MODELS