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FLASH GENE

Symbol

NPAS4

contributors: shn/mct - updated : 26-06-2015

HGNC name	neuronal PAS domain protein 4
HGNC id	18983

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   highly in ischemic tissues following both focal and global cerebral ischemic insults

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   could be a novel therapeutic target in type 2 diabetes that could both reduce ER stress and cell death and maintain basal cell function

ANIMAL & CELL MODELS

	Npas4 knockout mice appear anxious and hyperactive, are prone to seizures and have a shortened lifespan compared with their wild-type littermates, phenotypically resembling other knockout mice lacking genes that control the formation
	or function of inhibitory circuits (Lin et al, 2008)