Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

TIAM1

contributors: mct - updated : 31-05-2022

HGNC name	TIAM Rac1 associated GEF 1
HGNC id	11805

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DDIDSDS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal cancer, especially in metastatic cases, associated with hypomethylation of promoter region in colorectal cancer tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	prognostic marker for esophageal squamous cell carcinoma (ESCC)
	may be a prognostic factor for the treatment of thyroid cancers
	may be a useful biomarker for therapeutic strategy and control in hepatocellular carcinoma (HCC) treatment
Therapy target
	System Type Disorder Pubmed cancer     pharmacologic reversal of promoter hypomethylation may inhibit cell proliferation and migration immunology inflammatory   activation of a TIAM1-Rac1 signaling module, is a potential novel therapeutic target against increased vascular permeability associated with inflammatory diseases cancer endocrine thyroid potential therapeutic target for the treatment of thyroid cancers immunology autoimmune multiple sclerosis TIAM1/RAC1 may be a therapeutic target in multiple sclerosis

ANIMAL & CELL MODELS

mice lacking Tiam1 have simplified dendritic arbors, reduced dendritic spine density, and diminished excitatory synaptic transmission in the dentate gyrus